Multi-site Cognitive Paradigms for fMRI studies

The cognitive and sensorimotor paradigms used in the Phase I Traveling Subjects (2003) and in the multisite clinical study (Phase II, 2004-2006) are available to the public.

These paradigms are available for anyone to use: Eprime Program Phase I and Eprime Programs Phase II. More paradigms used in multi-site studies are being made available.

Current recommendations on developing multi-site fMRI paradigms, and implementing them successfully, are available as part of the FBIRN Best Practices FAQ.

The Phase I and Phase II paradigms include:

  • Sensorimotor tasks: Two versions of a sensorimotor task (with and without auditory stimuli, with 3Hz finger tapping or with 2Hz irregular finger tapping; one set up for 3 s TR and one for 2 s TR)
  • Breath hold tasks: Two versions of a Breathhold task (one set up for a 3 s TR, using a visual circle as a cue to breathe or not; one for a 2 s TR, using red/yellow/green to cue breathing).
  • Working memory tasks: Two versions of a Serial Item Recognition Paradigm (with and without an explicit motor baseline condition; one set up for 3 s TR and one for 2s TR)
  • An Auditory Oddball Task

The paradigms were programmed in E-Prime and assume that each site has that software and the PST Stimulus Response Box available, though they can be modified to work with other response devices.

  • For more information regarding the Cognitive Working Group in FBIRN, please view the presentations here.
BIRN is supported by NIH grants 1U24-RR025736, U24-RR021992, U24-RR021760 and by the Collaborative Tools Support Network Award 1U24-RR026057-01.